Extracellular polysaccharides play a central role in the survival capabilities of caries-causing bacteria in dental plaque, report researchers from the University of Basel’s Preventative Dentistry and Oral Microbiology Clinic and Department of Biomedical Engineering in the journal PLOS ONE.
Cariogenic bacteria live in biofilm and attack dental enamel by converting sugar and starch into acids that dissolve out calcium from the enamel. This process can cause caries. The dissolution of calcium increases the concentration of calcium locally, creating an environment that is hostile to bacterial life. In their study, the researchers investigated how bacteria manage to survive in dental plaque despite these conditions.
They hypothesized that extracellular polysaccharides (EPS) support the bacteria’s survival capabilities. EPS are substances that build extracellular cariogenic bacteria from sugar residue. They create the biofilm’s scaffolding and ensure that bacteria are able to anchor themselves in the dental plaque.
EPS integrate calcium into the biofilm
The study showed that the more calcium cariogenic bacteria dissolve, the greater their calcium tolerance and survival capability in the biofilm becomes. The scientists were able to prove that cariogenic bacteria develop mechanisms to help them survive the high concentrations of calcium.
They demonstrated that extracellular polysaccharides possess a high number of calcium binding sites through which they can integrate the free calcium into the biofilm. This neutralizes the toxic substance and strengthens the EPS structure of the biofilm.
New insights into the causes of caries
The EPS’ integration of calcium doesn’t just help cariogenic bacteria to survive in dental enamel; it also causes caries. “EPS’ integration of calcium inhibits the remineralization of the enamel, as there is no longer sufficient free calcium present in the plaque. This discovery is important in gaining a better understanding of calcium regulation in caries,” explains microbiologist Monika Astašov-Frauenhoffer.
credit : source
This entry How caries-causing bacteria can survive in dental plaque — one of Dentine.info - Dental care information ideas and was posted on Tuesday, June 26th, 2018 5:00 am. To explore more entry of the "How caries-causing bacteria can survive in dental plaque —" you can browse these Dentistry or bowse by
How caries-causing bacteria can survive in dental plaque —, the most important thing is dentist qualification. Make sure the dentist is licensed in the country where he or she practices. Look for his mandate, the dental school he graduated and their experience in this field. How caries-causing bacteria can survive in dental plaque — It is very important to find the right dentist for your dental needs that you like. When looking for a good dental clinic, make sure you choose a place where you will receive the attention you need. How caries-causing bacteria can survive in dental plaque — It needs to be opened comfortably and offers emergency and extended services to its patients. Low cost, affordable dental care and care at the dental office are equally important.